2018年新通过的OECD测试准则，了解一下！

OECD Test Guidelines - Environmental Fate And Behavior

1

Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP)

2

Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)

No.

OECD Test Guidelines - Health Effects

1

Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents

mirrors updates to TG 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)

2

Test No. 412: Subacute Inhalation Toxicity: 28-Day Study

3

Test No. 413: Subchronic Inhalation Toxicity: 90-day Study

4

Test No. 414: Prenatal Development Toxicity Study

5

Test No. 451: Carcinogenicity Studies

6

Test No. 452: Chronic Toxicity Studies

7

Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies

8

Test No. 442B: Skin Sensitization: Local lymph node assay: BRDU-ELISA or -FCM

9

Test No. 443: Extended One-Generation Reproductive Toxicity Study

10

Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

11

Test No. 442D: In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method

12

Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

13

Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

14

Test No. 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation

15

Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure