The Toxic Substances Control Act, namely TSCA, was enacted by the US Congress in 1976 and came into effect in 1977, implemented by the US Environmental Protection Agency (EPA). The Act intends to prevent unreasonable risks of injury to human health or the environment as well as to limit, prohibit, or ban chemical substances posing imminent hazards. With several amendments, TSCA has become a prominent regulation for effective chemical substance management. Much attention shall be paid to TSCA compliance by manufacturers and importers with regulatory obligations.