China Issues a New Cosmetics Supplementary Testing Method: Five Imidazoline Drugs Involved
The new cosmetic supplementary testing method applies to five imidazoline drugs such as Tetrahydrozoline and Naphazoline in cream, lotion, liquid (water), gel, and wax-based cosmetics.Up to now, China has approved six cosmetic supplementary testing methods.
On December 23, 2022, China NMPA released a new cosmetics supplementary testing method, BJH 202204 Determination of Five Components Including Tetrahydrozoline in Cosmetics, which specifies the qualitative and quantitative determination method of the following five prohibited ingredients.
| No. | Ingredient Name (CAS No.) | Detection Limit (μg/L) | Lower Quantitative Limit (μg/L) | Detection Concentration (mg/kg) | Minimum Quantitative Concentration (mg/kg) |
| 1 | Tetrahydrozoline (84-22-0) | 0.0016 | 0.005 | 0.08 | 0.25 |
| 2 | Naphazoline (835-31-4) | 0.0016 | 0.005 | 0.08 | 0.25 |
| 3 | Oxymetazoline (1491-59-4) | 0.0016 | 0.005 | 0.08 | 0.25 |
| 4 | Antazoline (91-75-8) | 0.0016 | 0.005 | 0.08 | 0.25 |
| 5 | Xylometazoline (526-36-3) | 0.0016 | 0.005 | 0.08 | 0.25 |
(Table 1 Five Imidazoline Drugs)
The five imidazoline drugs are mainly used in the medical field but are not allowed to be used in cosmetics. The new method is applicable for the determination of these ingredients in the cream, lotion, liquid (water), gel, and wax-based cosmetics.
[Read more at ChemLinked]
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